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李承叡 教授

E-mail: chengrueilee@ntu.edu.tw
電話: (02) 3366-2535
專長: 演化遺傳學、演化基因體學、數量性狀遺傳學、遺傳定位
學歷: 美國杜克大學博士

研究室: 生命科學館1129室
 

近年研究主題

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雜草植物演化的遺傳及基因體機制
經濟作物野外近緣種的族群演化 

研究室簡介

我們對生態演化遺傳學與基因體學的相關研究都很感興趣，主題物種不拘，主軸在於瞭解基因，基因體，環境，性狀，還有天擇之間如何交互作用及影響彼此。你最有興趣的物種是什麼？加入我們的團隊，讓我們一起發掘他背後有趣的故事吧！
我們的研究使用許多跨領域的知識，整合了野外生態學，族群遺傳學，數量性狀遺傳學，分子生物學，基因體學， 及生物資訊學的知識及技術來回答有趣的生態演化問題。有興趣加入我們團隊的學生應該對演化學有高度的興趣。對上述某些領域有涉獵有加分，但不是絕對必須的。
舉例來說, 我們對這些問題很有興趣：

  1. 棲地適應會促進物種分化嗎?

  2. 為什麼會有遺傳多樣性存在? 是什麼維持遺傳多樣性?

  3. 什麼因素會影響遺傳多樣性的地理分佈?

  4. 為什麼基因體裡的某些位點會比其他區域有更多的多樣性?

  5. 控制性狀的基因體區塊/基因是哪些?

  6. 這些適應環境的性狀是被少數幾個基因控制(每個基因都對性狀具有重大影響)，或是被很多基因控制(每個基因單獨對性狀只有微小的影響)？

  7. 這些適應特殊環境的對偶基因是怎麼來的? 是新突變還是族群中已有的遺傳多樣性? 

除此之外，我們也對與人類相關的物種(雜草如阿拉伯芥，或農作物如稻米及黃豆)和他們野外近緣種間的演化關係很有興趣。本團隊竭誠歡迎對生態演化遺傳學與基因體學有熱誠的研究新血加入！ 

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代表著作

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  1. N Fumia, R Nair, Y-P Lin, C-R Lee, H-W Chen, E Bishop-von-Wettberg, M Kantar, R Schafleitner*. 2023 Dec. Leveraging genomics and phenomics to accelerate improvement in mungbean: A case study in how to go from GWAS to selection. The Plant Phenome Journal doi:10.1002/ppj2.20088

  2. PS Chien, P-H Chen, C-R Lee*, T-J Chiou*. 2023 Sept. Transcriptome-wide association study coupled with eQTL analysis reveals the genetic connection between gene expression and flowering time in Arabidopsis. Journal of Experimental Botany 74(18):5653-5666

  3. Y-P Lin#, H-W Chen#, P-M Yeh, SS Anand, J Lin, J Li, T Noble, R Nair, R Schafleitner, M Samsonova, E Bishop-von-Wettberg, S Nuzhdin, CT Ting, RJ Lawn, C-R Lee*. 2023 Oct. Demographic history and distinct selection signatures of two domestication genes in mungbean. Plant Physiology 193(2):1197-1212

  4. ​Carley, L.N., Mojica, J.P., Wang, B., Chen, C.-Y., Lin, Y.-P., Prasad, K.V.S.K., Chan, E., Hsu, C.-W., Keith, R., Nuñez, C.L., Olson-Manning, C.F., Rushworth, C.A., Wagner, M.R., Wang, J., Yeh, P.-M., Reichelt, M., Ghattas, K., Gershenzon, J., Lee, C.-R.*, and Mitchell-Olds, T. (2021). Ecological factors influence balancing selection on leaf chemical profiles of a wildflower. Nature Ecology & Evolution.

  5. H. Matsumura, M.-C. Hsiao, Y.-P. Lin, A. Toyoda, N. Taniai, K. Tarora, N. Urasaki, S. S. Anand, N. P. S. Dhillon, R. Schafleitner, and C.-R. Lee*. Long-read bitter gourd (Momordica charantia) genome and the genomic architecture of nonclassic domestication.P.N.A.S. Jun 2020, 117 (25) 14543-14551; DOI: 10.1073/pnas.1921016117.

  6. Lee, C-R, B Wang , JP Mojica, T Mandakova, KVSK Prasad, JL Goicoechea, N Perera, U Hellsten, HN Hundley, J Johnson, J Grimwood, K Barry, S Fairclough, JW Jenkins, Y Yu, D Kudrna, J Zhang, J Talag, W Golser, K Ghattas, ME Schranz, R Wing, MA Lysak, J Schmutz, DS Rokhsar and T Mitchell-Olds. 2017. Young inversion with multiple linked QTLs under selection in a hybrid zone. Nature Ecology & Evolution 1: 0119

  7. Lee, C-R, H Svardal, A Farlow, M Exposito-Alonso, W Ding, P Novikova, C Alonso-Blanco, D Weigel, and M Nordborg. 2017. On the post-glacial spread of human commensal Arabidopsis thaliana. Nature Communications 8: 14458

  8. The 1001 Genomes Consortium. 2016. 1135 genomes reveal the global pattern of polymorphism in Arabidopsis thaliana. Cell 166:481-491

  9. Lee, C-R, JT Anderson, and T Mitchell-Olds. 2014. Unifying genetic canalization, genetic constraint, and genotype-by-environment interaction: QTL by genomic background by environment interaction of flowering time in Boechera stricta. PLoS Genetics 10(10):e1004727

  10. Lee, C-R and T Mitchell-Olds. 2013. Complex trait divergence contributes to environmental niche differentiation in ecological speciation of Boechera stricta. Molecular Ecology 22(8):2204-2217 

  11. Lee, C-R and T Mitchell-Olds. 2012. Environmental adaptation contributes to gene polymorphism across the Arabidopsis thaliana genome. Molecular Biology and Evolution 29(12):3721-3728 

  12. Prasad, K, B-H Song, C Olson-Manning, JT Anderson, C-R Lee, ME Schranz, AJ Windsor, MJ Clauss, AJ Manzaneda, I Naqvi, M Reichelt, J Gershenzon, SG Rupasinghe, MA Schuler, and T Mitchell-Olds. 2012. A gain-of-function polymorphism controlling complex traits and fitness in nature. Science 337:1081-1084

  13. Lee, C-R and T Mitchell-Olds. 2011. Quantifying effects of environmental and geographical factors on patterns of genetic differentiation. Molecular Ecology 20(22):4631- 4642

​其他著作

  1. 臺大團隊探索抗蟲、抗旱、與基因重複之間的危險平衡，形塑野生芥末「口味」的多樣性！

開設課程

  • EEB7002專題研究

  • EEB5045族群遺傳學 (合授) 

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